41. Huntington’s disease, that was recently seen in news, primarily affects which part of the body?
[A] Lungs
[B] Brain
[C] Kidneys
[D] Heart
Show Answer
Correct Answer: B [Brain]
Notes:
Huntington’s Disease (HD) is not yet included in the rare disease category under the National Policy for Rare Diseases despite demands from patients and caregivers in 2024. It is a genetic condition that affects brain cells, causing them to slowly lose function and die. It is inherited, with a 50% chance of passing from an affected parent to a child. It impacts brain regions controlling voluntary movement, memory, thinking, and decision-making, including the basal ganglia and cortex.
42. Which organisation launched CEREBO, the portable device for rapid, radiation-free diagnosis of traumatic brain injuries?
[A] Indian Council of Medical Research
[B] Indian Red Cross Society
[C] Indian Institute of Health Management Research
[D] Ministry of Science and Technology
Show Answer
Correct Answer: A [Indian Council of Medical Research ]
Notes:
On 21 August 2025, the Indian Council of Medical Research (ICMR) launched CEREBO, a portable non-invasive device to detect traumatic brain injuries (TBI). It uses near-infrared spectroscopy with machine learning to identify intracranial bleeding and edema within one minute, giving colour-coded, radiation-free results. The device is safe for infants and pregnant women and can be operated by paramedics or unskilled staff with just 30 minutes of training. It was developed by ICMR, AIIMS Bhopal, NIMHANS Bengaluru and Bioscan Research. India records over 1 lakh deaths and 10 lakh serious head injuries annually, making early TBI detection critical.
43. Glanders disease, that was recently seen in news, is caused by which agent?
[A] Bacteria
[B] Virus
[C] Fungus
[D] Protozoa
Show Answer
Correct Answer: A [Bacteria]
Notes:
The Department of Animal Husbandry & Dairying (DAHD) under the Ministry of Fisheries, Animal Husbandry & Dairying has recently issued the Revised National Action Plan on Glanders. Glanders is caused by the bacterium Burkholderia mallei and mainly affects equines like horses, mules, and donkeys, with risks to other animals and humans. It causes nodules and ulcerations in the respiratory tract and lungs, with a skin form known as farcy. Transmission occurs through contaminated food or water, infected harness equipment, or horse meat. It is a World Organisation for Animal Health (WOAH)-listed disease and must be notified under the WOAH Terrestrial Animal Health Code.
44. Lunar Polar Exploration (LUPEX) programme is jointly developed by which two space agencies?
[A] National Aeronautics and Space Administration (NASA) and European Space Agency (ESA)
[B] China National Space Administration (CNSA) and European Space Agency (ESA)
[C] Indian Space Research Organisation (ISRO) and European Space Agency (ESA)
[D] Japan Aerospace Exploration Agency (JAXA) and Indian Space Research Organisation (ISRO)
Show Answer
Correct Answer: D [Japan Aerospace Exploration Agency (JAXA) and Indian Space Research Organisation (ISRO)]
Notes:
Prime Minister of India welcomed the agreement between Indian Space Research Organisation (ISRO) and Japan Aerospace Exploration Agency (JAXA) for the Chandrayaan-5 mission under the Lunar Polar Exploration (LUPEX) programme. LUPEX is jointly developed by ISRO and JAXA to explore the Moon’s southern polar region. The mission aims to investigate the presence of water and other elements, potentially as surface ice, and demonstrate innovative surface exploration technologies. It features a lander developed by ISRO and a rover developed by JAXA. The rover will autonomously search for water-rich areas, drill, sample soil, and analyze it with onboard instruments.
45. Which institute has developed cholesterol-based nanomaterials for quantum technologies and spintronic applications?
[A] Indian Institute of Technology, Delhi
[B] Institute of Nano Science and Technology, Mohali
[C] Indian Institute of Technology, Bombay
[D] Tata Institute of Fundamental Research
Show Answer
Correct Answer: B [Institute of Nano Science and Technology, Mohali]
Notes:
Cholesterol, a fat-like substance, can control the spin of electrons, a quantum property crucial for next-generation spintronic devices. Spintronics uses electron spin to develop energy-efficient electronics and bioelectronic devices. Scientists from the Institute of Nano Science and Technology (INST), Mohali, under the Department of Science and Technology (DST), developed cholesterol-based nanomaterials for spintronic and quantum applications. Cholesterol’s intrinsic handedness (chirality) and flexibility allow precise control over molecular properties. This innovation could enable energy-efficient memory chips and greener quantum technologies.
46. Which organization developed India’s first indigenous multi-stage malaria vaccine (AdFalciVax)?
[A] Indian Council of Medical Research (ICMR)
[B] National Institute of Virology (NIV)
[C] All India Institute of Medical Sciences (AIIMS) New Delhi
[D] Serum Institute of India
Show Answer
Correct Answer: A [Indian Council of Medical Research (ICMR)]
Notes:
India has licensed Indian Immunologicals Limited, Techinvention Lifecare Private Limited, Panacea Biotec Limited, Biological E Limited, and Zydus Lifesciences for manufacturing its first indigenous multi-stage malaria vaccine (AdFalciVax). The vaccine was developed by Indian Council of Medical Research (ICMR) and partners. It targets Plasmodium falciparum before it enters the bloodstream to prevent transmission. The vaccine is affordable, stable, scalable, and effective for over 9 months at room temperature.
47. Where was the Gyan Bharatam International Conference 2025 held?
[A] Bengaluru
[B] Mumbai
[C] Chennai
[D] New Delhi
Show Answer
Correct Answer: D [New Delhi]
Notes:
Union Culture Minister Gajendra Singh Shekhawat inaugurated the Gyan Bharatam International Conference in New Delhi on 11 September. Gyan Bharatam is a national initiative for preserving, digitising, and disseminating India’s manuscript heritage. The mission envisions 25 clusters, 20 regional centres, and 10 centres of excellence to safeguard manuscripts. The conference brought together 1,100+ participants, including scholars, experts, institutions, and cultural practitioners from India and abroad.
48. Which country’s scientists developed a simpler portable ion chromatograph called Aquamonitrix for field use?
[A] India
[B] Australia
[C] Germany
[D] New Zealand
Show Answer
Correct Answer: B [Australia]
Notes:
Scientists at the University of Tasmania, Australia, developed a portable ion chromatograph called Aquamonitrix to perform ion separation in the field. The device was tested by undergraduate students who analysed soil pore water for harmful nitrate and nitrite ions immediately after collection. Results were comparable to expensive lab-based chromatographs, proving accuracy with lower cost and time. Aquamonitrix uses sodium chloride solution and a UV absorbance detector, making it simple, eco-friendly, and effective. The portable device costs about $10,000 versus $100,000 for conventional lab instruments. It provides hands-on field experience for students, linking theory with real-world environmental analysis.
49. Japanese Encephalitis (JE), that was recently seen in news, is caused by which agent?
[A] Bacteria
[B] Virus
[C] Fungus
[D] Protozoa
Show Answer
Correct Answer: B [Virus]
Notes:
Mosquito-borne diseases like dengue fever are rising due to rapid urbanisation, climate change, and global travel. A new study published on 3 September in Science Translational Medicine shows waning immunity against Japanese Encephalitis Virus (JEV) can worsen dengue outcomes. Japanese Encephalitis (JE) is a viral zoonotic disease caused by the Japanese Encephalitis (B) virus. Transmission occurs through infected Culex mosquitoes of the Vishnui group, not from human to human. It is most common in rural Asia, especially during monsoon seasons. Both viruses belong to the genus Orthoflavivirus and show cross-immune interactions.
50. What is the name of the half-humanoid robot that ISRO will send in December 2025 as part of the first uncrewed Gaganyaan mission?
[A] Aditya
[B] Vyommitra
[C] Kaveri
[D] Talwar
Show Answer
Correct Answer: B [Vyommitra]
Notes:
ISRO Chief V. Narayanan announced that a half-humanoid robot Vyommitra will be sent in December 2025 as part of the first uncrewed Gaganyaan mission. Two more uncrewed missions are planned in 2026 before sending India’s first astronaut, Gaganyatri, to space in early 2027. ISRO successfully conducted the first Integrated Air Drop Test (IADT-01) for the parachute-based deceleration system with support from the Indian Air Force, DRDO, Navy, and Coast Guard. Human Rated Launch Vehicle (HLVM3), Crew Escape System, and propulsion systems have been tested.