41. Human Outer Planetary Exploration (HOPE) is a moon and Mars simulation research station located in which state/UT?
[A] Lakshadweep
[B] Ladakh
[C] Goa
[D] Tamil Nadu
Show Answer
Correct Answer: B [Ladakh]
Notes:
Recently, Bengaluru-based space company Protoplanet launched the Human Outer Planetary Exploration (HOPE) station in Ladakh’s Tso Kar region. HOPE is a moon and Mars simulation research station mimicking off-Earth terrain and environment. It is located in the high-altitude cold desert of Tso Kar basin, Ladakh. The project is developed by Protoplanet with technical and financial support from Indian Space Research Organisation (ISRO). It aims to study human psychological, physiological, and epigenetic responses in extreme isolation. It supports India’s long-term space goals including a crewed lunar mission by 2040 and a space station by 2035.
42. Pneumococcal disease, that was recently seen in news, is caused by which agent?
[A] Virus
[B] Bacteria
[C] Fungus
[D] Protozoa
Show Answer
Correct Answer: B [Bacteria]
Notes:
Pfizer recently launched its 20-valent pneumococcal conjugate vaccine (PCV20) for adults in India. PCV20 protects against 20 serotypes causing most pneumococcal diseases. Pneumococcal disease is caused by the bacterium Streptococcus pneumoniae. It can cause mild infections like ear infections and severe ones like pneumonia, meningitis, and bloodstream infections. Around 90 serotypes exist globally; few cause most diseases. It is a major global health issue, especially affecting young children and the elderly in developing countries.
43. Chagas disease, that was recently seen in news, is caused by which agent?
[A] Virus
[B] Bacteria
[C] Fungus
[D] Protozoa
Show Answer
Correct Answer: D [Protozoa]
Notes:
Recently, concern was raised that despite the huge human and economic toll of Chagas disease, investment in research and development of diagnostics, medicines, and vaccines remains disproportionately low. Chagas disease, or American trypanosomiasis, is caused by the protozoan parasite Trypanosoma cruzi. It spreads mainly through blood-sucking triatomine bugs, also called reduviid or “kissing bugs,” which often bite the face. Infection occurs when parasite-containing feces of the bug enter the body. It can also spread from mother to child, contaminated food or drinks, blood transfusions, organ transplants, or lab accidents. The disease is common in South America, Central America, and Mexico.
44. Which country has launched 11 GEESATCOM (Geely Constellation) for Internet of Things (IoT) communication?
[A] China
[B] Russia
[C] Iran
[D] Israel
Show Answer
Correct Answer: A [China]
Notes:
On 15 August 2025, Chinese commercial aerospace company Geespace successfully completed the fourth orbital deployment of GEESATCOM (Geely Constellation) by launching 11 satellites from waters off Rizhao, Shandong Province aboard a single rocket. All satellites entered their planned 600 km orbits and are operating normally. GEESATCOM, independently developed and operated by Geespace, supports satellite Internet of Things (IoT) testing and inter-satellite communications. It also provides Earth observation for ecological and environmental monitoring.
45. Which NASA mission recently spotted two rocky exoplanets orbiting the star TOI-2322?
[A] Transiting Exoplanet Survey Satellite (TESS)
[B] Artemis Program
[C] James Webb Space Telescope
[D] Hubble Space Telescope
Show Answer
Correct Answer: A [Transiting Exoplanet Survey Satellite (TESS)]
Notes:
NASA’s Transiting Exoplanet Survey Satellite (TESS) mission has discovered two rocky exoplanets around star TOI-2322, located 195 light-years away. Scientists detected them by observing small dips in the star’s brightness, indicating planets passing in front. TOI-2322 b is nearly Earth-sized, completes one orbit in 11 days, and has a very hot surface temperature of about 330°C. TOI-2322 c is almost twice Earth’s size, about 18 times heavier, and has a dense structure similar to Earth’s layers. The planets were confirmed using space telescopes and ground tools, showing successful global collaboration in astronomy.
46. Which institute discovered that protein p47 acts as a “mechanical chaperone”, enhancing protein stability under mechanical stress?
[A] Indian Institute of Science (IISc), Bengaluru
[B] S. N. Bose National Centre for Basic Sciences (SNBNCBS), Kolkata
[C] National Chemical Laboratory (NCL), Pune
[D] Centre for Cellular and Molecular Biology (CCMB), Hyderabad
Show Answer
Correct Answer: B [S. N. Bose National Centre for Basic Sciences (SNBNCBS), Kolkata]
Notes:
Researchers at S. N. Bose National Centre for Basic Sciences (SNBNCBS) discovered protein p47’s new role as a “mechanical chaperone.” P47 is a cofactor protein known for assisting p97 in protein trafficking, degradation, and membrane fusion. Study revealed p47 boosts mechanical efficiency of protein extraction from endoplasmic reticulum (ER) to cytoplasm. It stabilizes polypeptides under stress, guides them through pores, prevents misfolding, and improves translocation. This is the first single-molecule evidence of autonomous, force-dependent chaperone-like activity by p47. Discovery opens new therapeutic possibilities for diseases linked to protein instability.
47. Which country has launched EnteroMix, a new mRNA-based cancer vaccine?
[A] Russia
[B] China
[C] India
[D] Australia
Show Answer
Correct Answer: A [Russia]
Notes:
Russia has launched EnteroMix, a new mRNA-based cancer vaccine, reported to show 100 percent efficacy in early trials. It was developed by the National Medical Research Radiology Centre (NMRRC) and Engelhardt Institute of Molecular Biology under the Russian Academy of Sciences. The launch took place at the St Petersburg International Economic Forum (SPIEF 2025) and shared globally via Sputnik news service. The vaccine targets colorectal cancer first, with versions in development for glioblastoma and melanoma. EnteroMix uses four harmless viruses to attack cancer cells and boost immune defence. Russian Federal Medical and Biological Agency (FMBA) confirmed its safety for repeated use and personalised RNA-based tailoring.
48. By using which method did scientists study fossil leaves from Nagaland to understand the evolution of Indian monsoons?
[A] Radiocarbon Dating
[B] Ice Core Analysis
[C] Dendrochronology
[D] CLAMP (Climate Leaf Analysis Multivariate Program)
Show Answer
Correct Answer: D [CLAMP (Climate Leaf Analysis Multivariate Program)]
Notes:
A study of fossil leaves from Nagaland revealed how Antarctica influenced the Indian Monsoons. Fossil leaves from the Laisong Formation in Nagaland revealed that the region once had a warm and wet climate with very high rainfall and temperatures. The fossils matched the period when massive ice sheets began forming in Antarctica, showing a global connection. Growth of Antarctic ice reshaped global wind and rainfall patterns by shifting the Intertropical Convergence Zone (ITCZ) toward the tropics. This shift brought intense monsoonal rains to Northeast India and led to the evolution of the monsoon system. The research used CLAMP (Climate Leaf Analysis Multivariate Program) method to analyze fossil leaves. CLAMP treats fossil leaves as “climate fingerprints” to reconstruct past climates.
49. Which garden was inaugurated in Lucknow at the National Botanical Research Institute (NBRI) during the CSIR Startup Conclave?
[A] Rose Garden
[B] Swastik Lotus Garden
[C] Mughal Garden
[D] Herbal Medicinal Garden
Show Answer
Correct Answer: B [Swastik Lotus Garden]
Notes:
Recently, the first-of-its-kind Swastik Lotus Garden was inaugurated at the National Botanical Research Institute (NBRI), Lucknow, during the CSIR Startup Conclave. The garden features 60 lotus varieties from across the world and 50 species of water lilies. Conservation is ensured through advanced genetic methods, light regulation, and scientific treatments. CSIR technologies were transferred to private companies for public access, including perfumes Frotus-Rudra, Frotus-Kumbh, air-freshener Frotus Fresh, green firecrackers, aromatherapy oil Relaxomap, and portable water analysis kits. The initiative strengthens scientific innovation, conservation, and entrepreneurship at grassroots and national levels.
50. Hand, Foot, and Mouth Disease (HFMD), that was recently seen in news, is caused by which agent?
[A] Bacteria
[B] Virus
[C] Fungus
[D] Protozoa
Show Answer
Correct Answer: B [Virus]
Notes:
A viral infection called Hand, Foot, and Mouth Disease (HFMD) is spreading rapidly among children in Delhi and Haryana, prompting advisories. It is a highly contagious illness caused by a virus. It causes blister-like rashes on hands and feet, painful mouth sores, and sometimes rashes on chest, back, arms, legs, genitals, and buttocks. It mostly affects infants and children under 5 years, spreading quickly in schools and daycare. It is different from foot-and-mouth disease in animals, caused by a different virus. Transmission happens through unwashed hands, saliva, mucus, feces, or blister fluid. No cure or vaccine exists; recovery usually takes 7–10 days with basic care. Complications are rare, but children under 2 may take longer to recover.