41. Leprosy (Hansen’s disease), that was recently seen in news, is caused by which agent?
[A] Bacteria
[B] Virus
[C] Fungus
[D] Protozoa
Show Answer
Correct Answer: A [Bacteria]
Notes:
The National Human Rights Commission (NHRC) reported that 97 central and state laws still have provisions discriminating against persons affected by leprosy. Leprosy (Hansen’s disease) is a chronic bacterial infection caused by bacteria Mycobacterium leprae affecting skin, peripheral nerves, and eyes, which can cause permanent disabilities if untreated. The bacteria spread through droplets from the nose and mouth during close, frequent contact with untreated cases. India’s prevalence rate decreased from 57.2 per 10,000 in 1981 to 0.57 per 10,000 in 2025, achieving national elimination status in 2005.
42. Which country has become the first in the African Region to eliminate onchocerciasis, also known as river blindness?
[A] Niger
[B] Rwanda
[C] Algeria
[D] Ethiopia
Show Answer
Correct Answer: A [Niger]
Notes:
Niger became the first country in the African Region to eliminate onchocerciasis, also called river blindness. Niger is the fifth country worldwide to stop transmission of Onchocerca volvulus parasite. Other successful countries are Colombia, Ecuador, Guatemala, and Mexico in the Americas. World Health Organisation (WHO) praised Niger’s strong leadership and public health efforts. Onchocerciasis is the second leading infectious cause of blindness after trachoma. It spreads through bites of infected black flies found near rivers. It mainly affects rural areas of sub-Saharan Africa and Yemen, and some parts of Latin America.
43. Haemorrhagic Septicaemia (HS) disease, that was recently seen in news, is caused by which agent?
[A] Bacteria
[B] Virus
[C] Fungus
[D] Protozoa
Show Answer
Correct Answer: A [Bacteria]
Notes:
Ten blackbucks died in Jamshedpur Zoological Park, Jharkhand due to suspected Haemorrhagic Septicaemia (HS). Haemorrhagic Septicaemia (HS) is also called Pasteurellosis and is caused by Pasteurella multocida bacteria. It mainly affects cattle and buffaloes, with young animals more vulnerable. Bacteria survive longer in humid and waterlogged conditions. It spreads through contaminated food, water, air and direct contact.
44. Which institution has developed an ingestible device capable of directly sampling bacteria from the small intestine?
[A] IIT Bombay
[B] IIT Delhi
[C] IIT Madras
[D] IIT Kanpur
Show Answer
Correct Answer: B [IIT Delhi]
Notes:
Researchers at the Indian Institute of Technology Delhi have developed an ingestible device that can directly sample bacteria from the small intestine. The innovation helps overcome limitations of current methods like endoscopy or stool analysis, which do not accurately reflect upper gut conditions. The pill-sized device remains closed in the stomach and opens only in the intestine to collect bacterial samples, then reseals safely. It uses an enteric-coated gelatin cap that dissolves at intestinal pH, allowing fluid and microbes to enter sampling chambers. The study was conducted in collaboration with the All India Institute of Medical Sciences Delhi and funded by the Indian Council of Medical Research.
45. Which institute has developed a peptide therapy for fungal keratitis, a severe infection of the cornea?
[A] All India Institute of Medical Sciences (AIIMS), Delhi
[B] Bose Institute, Kolkata
[C] Indian Institute of Science (IISc), Bengaluru
[D] Indian institute of Technology (IIT), Delhi
Show Answer
Correct Answer: B [Bose Institute, Kolkata]
Notes:
Researchers from Bose Institute, Kolkata, in collaboration with L V Prasad Eye Institute, Hyderabad, have developed a peptide therapy for fungal keratitis, a severe infection of the cornea. They designed a 15-residue peptide, SA-XV, derived from the host-defense peptide S100A12, previously known to inhibit fungal growth. SA-XV acts by interacting with fungal cell walls and membranes, translocating into the cytoplasm, binding nuclear DNA to halt the cell cycle, and targeting mitochondria to induce apoptosis.
46. Kavach 4.0, an Automatic Train Protection (ATP) system, has been commissioned in Gujarat on which railway section?
[A] Surat–Vadodara
[B] Vadodara–Ahmedabad
[C] Ahmedabad–Rajkot
[D] Vadodara–Bharuch
Show Answer
Correct Answer: B [Vadodara–Ahmedabad]
Notes:
Kavach 4.0 has been commissioned on Gujarat’s first Bajwa (Vadodara)–Ahmedabad 96 km section. The section covers 17 stations with 23 towers, 20 Kavach huts, 192 km optical fibre cable and 2,872 Radio Frequency Identification (RFID) tags. Kavach is an indigenously developed Automatic Train Protection (ATP) system of Indian Railways. Kavach 4.0 prevents Signal Passed at Danger (SPAD) and head-on or rear-end collisions. It enforces automatic speed control and Permanent Speed Restrictions. Kavach is certified to Safety Integrity Level-4 (SIL-4) and approved by Research Designs and Standards Organisation (RDSO)
47. India has inaugurated the world’s second National Environmental Standard Laboratory (NESL) in which city?
[A] Bengaluru
[B] New Delhi
[C] Chennai
[D] Hyderabad
Show Answer
Correct Answer: B [New Delhi]
Notes:
India inaugurated the world’s second National Environmental Standard Laboratory (NESL) and the world’s fifth National Primary Standard Facility for Solar Cell Calibration at CSIR–National Physical Laboratory (NPL), New Delhi. NESL will provide India-specific calibration and certification of air pollution monitoring systems, supporting regulatory bodies, industries, and startups, and improving policy enforcement under programmes like the National Clean Air Programme (NCAP).
48. Which institute developed the Raman Driven Spin Noise Spectroscopy (RDSNS) technique?
[A] Indian Institute of Science (IISc), Bengaluru
[B] Raman Research Institute (RRI), Bengaluru
[C] Tata Institute of Fundamental Research (TIFR), Mumbai
[D] National Physical Laboratory (NPL), Delhi
Show Answer
Correct Answer: B [Raman Research Institute (RRI), Bengaluru]
Notes:
Scientists at the Raman Research Institute (RRI), Bengaluru have developed a novel, non-invasive technique to measure the local density of cold atoms in real time without disturbing their quantum state. The method, called Raman Driven Spin Noise Spectroscopy (RDSNS), overcomes limitations of conventional atom-imaging methods used in cold atom experiments. Cold atoms, cooled near absolute zero, are crucial for quantum computing, quantum sensing, and precision measurement, but traditional detection methods like absorption and fluorescence imaging are often destructive or slow.
49. Vera C. Rubin Observatory, that was recently seen in news, is located in which country?
[A] Russia
[B] Germany
[C] China
[D] Chile
Show Answer
Correct Answer: D [Chile]
Notes:
Scientists used first images from the Vera C. Rubin Observatory to discover the fastest-spinning asteroid of its size, named 2025 MN45. The Vera C. Rubin Observatory is located on Cerro Pachón in the Chilean Andes at 8,684 feet altitude. It is named after astronomer Vera C. Rubin, who provided early evidence for dark matter. It is jointly funded by the United States National Science Foundation (NSF) and the United States Department of Energy (DoE). Its goals include studying dark matter and dark energy, mapping the Milky Way, tracking asteroids and comets, and observing changing cosmic objects.
50. What is ‘Param Shakti’ that was recently seen in news?
[A] A satellite launch vehicle
[B] An indigenously developed supercomputing system
[C] A defence missile programme
[D] A semiconductor fabrication unit
Show Answer
Correct Answer: B [An indigenously developed supercomputing system]
Notes:
IIT Madras launched Param Shakti, an indigenously developed supercomputing system with a capacity of 3.1 petaflop, meaning 3.1 quadrillion calculations per second. It is among India’s most powerful supercomputers and will help solve complex research problems faster and more accurately. The system will support advanced research in aerospace, materials, climate modelling, drug discovery, and manufacturing. Param Shakti is built entirely in India by the Centre for Development of Advanced Computing using the RUDRA server series and open-source software. It is integrated into the Param Rudra supercomputing cluster with advanced power, cooling, and data centre support.