41. Motor Neuron Disease (MND), that was recently seen in news, primarily affects which part of the human body?
[A] Circulatory system
[B] Nervous system
[C] Digestive system
[D] Endocrine system
Show Answer
Correct Answer: B [Nervous system]
Notes:
Scientists have recently developed a breakthrough therapy that clears toxic proteins from nerve cells, offering new hope for treating Motor Neuron Disease (MND). Motor Neuron Disease (MND), also known as Amyotrophic Lateral Sclerosis (ALS) or Lou Gehrig’s Disease, is a rare condition that damages parts of the nervous system. It causes muscle weakness, wasting, and paralysis as motor neurons in the brain and spinal cord die prematurely, stopping signals between the brain and muscles. Around 20% of cases are genetic, mostly affecting people over 50 years old. There is currently no cure, but treatment helps manage symptoms.
42. Where was India’s first indigenous high-precision compact diode laser launched?
[A] Bengaluru
[B] New Delhi
[C] Mumbai
[D] Kolkata
Show Answer
Correct Answer: B [New Delhi]
Notes:
In November 2025, Union Minister of State Dr. Jitendra Singh launched India’s first indigenous high-precision compact diode laser at the Emerging Science, Technology and Innovation Conclave 2025 (ESTIC 2025) held at Bharat Mandapam, New Delhi. The laser enables quantum-encrypted communication using Quantum Key Distribution (QKD), strengthening cybersecurity for financial and banking transactions. It is developed by Prenishq Pvt. Ltd., a startup supported by the National Quantum Mission (NQM), along with contributions from IIT-Delhi. The system offers high beam quality, strong stability, long-term reliability, and easy integration with lab and industrial setups.
43. Which state has launched KEO, a compact, affordable and AI-ready personal computer, in November 2025?
[A] Karnataka
[B] Kerala
[C] Maharashtra
[D] Gujarat
Show Answer
Correct Answer: A [Karnataka]
Notes:
On November 17, 2025, Karnataka’s Department of Electronics, IT & BT, with KEONICS, launched KEO, a compact, affordable and AI-ready personal computer designed entirely in Karnataka. KEO stands for Knowledge-driven, Economical, Open-source, built on an open-source RISC-V processor with a Linux-based OS. It features an on-device AI core that works without internet and includes BUDDH, an AI agent trained on the Karnataka DSERT syllabus to help students in low-connectivity areas. KEO will be deployed across schools, universities, businesses, homes and government offices, supporting locally adaptable, home-grown computing.
44. What is the name of India’s first indigenous CRISPR-based gene therapy for Sickle Cell Disease?
[A] SCD-CURE
[B] GEN-EDIT 1
[C] BIRSA 101
[D] HematoGene
Show Answer
Correct Answer: C [BIRSA 101]
Notes:
India’s first indigenous CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)-based gene therapy for Sickle Cell Disease (SCD), named BIRSA 101, was recently launched by the Union Minister of State (Independent Charge) for Science & Technology. It is developed by CSIR (Council of Scientific and Industrial Research) – Institute of Genomics and Integrative Biology (IGIB). BIRSA 101 uses CRISPR-Cas9 gene-editing technology to precisely correct the genetic mutation causing SCD. The therapy is administered as a one-time infusion, after which the body produces normal red blood cells instead of sickle-shaped ones.
45. Which organizations have indigenously built the India’s first private PSLV rocket?
[A] Hindustan Aeronautics Limited and L&T – Larsen & Toubro
[B] Defence Research and Development Organisation and Tata Group
[C] Indian Space Research Organisation and BHEL – Bharat Heavy Electricals Limited
[D] Bharat Electronics Limited and Defence Research and Development Organisation
Show Answer
Correct Answer: A [Hindustan Aeronautics Limited and L&T – Larsen & Toubro]
Notes:
The Hindustan Aeronautics Limited (HAL)–Larsen & Toubro (L&T) consortium has indigenously built India’s first private Polar Satellite Launch Vehicle (PSLV). The PSLV is scheduled to launch the Oceansat satellite early next year. India’s Indian Space Research Organisation (ISRO) signed a 2022 contract with the HAL–L&T consortium for end-to-end production of five PSLV-XL rockets. This move shifts PSLV manufacturing from ISRO to industry partners while ISRO focuses on new missions and research. The consortium has faced production challenges, resolved with ISRO’s support. HAL also received technology for the Small Satellite Launch Vehicle (SSLV) to fully own and operate its production.
46. The Entrepreneur-in-Residence (EIR) Programme is implemented by which government department?
[A] Department for Promotion of Industry and Internal Trade
[B] Department of Biotechnology
[C] Department of Commerce
[D] Department of Science and Technology
Show Answer
Correct Answer: D [Department of Science and Technology ]
Notes:
The Entrepreneur-in-Residence Programme is becoming popular among young startups and innovators. It works under the National Initiative for Developing and Harnessing Innovations which is NIDHI. It encourages graduate students to choose entrepreneurship as a career. It provides financial and non-financial support in the form of a fellowship. It offers startup infrastructure, mentoring, technical guidance, and industry support. It is implemented by the Department of Science and Technology with NCL Venture Centre.
47. Where is the headquarters of International Astronomical Union (IAU) located?
[A] Paris
[B] Geneva
[C] Rome
[D] Beijing
Show Answer
Correct Answer: A [Paris]
Notes:
A 3.5-billion-year-old crater on Mars is named after Indian geologist M. S. Krishnan. The naming was approved by the International Astronomical Union. The International Astronomical Union was founded in 1919. It promotes astronomy research, education, and global cooperation. It standardizes astronomical constants and naming of celestial bodies. It alone has the authority to name planets, craters, and space features. It holds a General Assembly every three years. Its headquarters is in Paris.
48. What is the name of India’s first manned deep-sea submersible mission?
[A] Gaganyaan
[B] Samudrayaan
[C] Sagaryaan
[D] Chandrayaan
Show Answer
Correct Answer: B [Samudrayaan]
Notes:
Samudrayaan is India’s first manned deep-ocean submersible mission to reach 6,000 metres depth. Testing is delayed due to late supply of syntactic foam from France, now expected by year-end after testing in Norway. The project is led by National Institute of Ocean Technology under the Ministry of Earth Sciences. A steel model has been tested up to 100 metres; a 500-metre trial is planned by April next year. The final titanium hull, built by Indian Space Research Organisation, will be tested in Russia. The mission will carry three crew members to collect seabed soil and rocks for future deep-sea mining.
49. GLP-1 Drug, that was recently seen in news, is used for the treatment of which disease?
[A] Foot and Mouth disease
[B] Typhoid
[C] Tuberculosis
[D] Obesity
Show Answer
Correct Answer: D [Obesity]
Notes:
The World Health Organization has issued the first global guidelines on Glucagon-Like Peptide-1 (GLP-1) drugs for weight loss. GLP-1 receptor agonists are synthetic medicines used to treat adult obesity and type-2 diabetes. These drugs are mainly injectable, while oral versions are under development. Leading examples are Semaglutide and Tirzepatide, now available in India. They increase insulin, reduce glucagon, slow stomach emptying, and suppress appetite, helping control blood sugar and body weight.
50. Haemorrhagic Septicaemia (HS) disease, that was recently seen in news, is caused by which agent?
[A] Bacteria
[B] Virus
[C] Fungus
[D] Protozoa
Show Answer
Correct Answer: A [Bacteria]
Notes:
Ten blackbucks died in Jamshedpur Zoological Park, Jharkhand due to suspected Haemorrhagic Septicaemia (HS). Haemorrhagic Septicaemia (HS) is also called Pasteurellosis and is caused by Pasteurella multocida bacteria. It mainly affects cattle and buffaloes, with young animals more vulnerable. Bacteria survive longer in humid and waterlogged conditions. It spreads through contaminated food, water, air and direct contact.