| Year |
Vaccine |
| 1796 |
Edward Jenner develops and documents first vaccine for smallpox. |
| 1880 |
First vaccine for cholera by Louis Pasteur |
| 1885 |
First vaccine for rabies by Louis Pasteur and Émile Roux |
| 1890 |
First vaccine for tetanus (serum antitoxin) by Emil von Behring |
| 1896 |
First vaccine for typhoid fever by Almroth Edward Wright, Richard Pfeiffer, and Wilhelm Kolle |
| 1897 |
First vaccine for bubonic plague by Waldemar Haffkine |
| 1921 |
First vaccine for tuberculosis by Albert Calmette |
| 1923 |
First vaccine for diphtheria by Gaston Ramon, Emil von Behring and Kitasato Shibasaburō |
| 1924 |
First vaccine for scarlet fever by George F. Dick and Gladys Dick |
| 1924 |
First inactive vaccine for tetanus (tetanus toxoid, TT) by the French Gaston Ramon, C. Zoeller and P. Descombey |
| 1926 |
First vaccine for pertussis (whooping cough) by Leila Denmark |
| 1932 |
First vaccine for yellow fever by Max Theiler and Jean Laigret |
| 1937 |
First vaccine for typhus by Rudolf Weigl, Ludwik Fleck and Hans Zinsser |
| 1937 |
First vaccine for influenza by Anatol Smorodintsev |
| 1941 |
First vaccine for tick-borne encephalitis |
| 1952 |
First vaccine for polio (Salk vaccine) |
| 1954 |
First vaccine for Japanese encephalitis |
| 1954 |
First vaccine for anthrax |
| 1957 |
First vaccine for adenovirus-4 and 7 |
| 1962 |
First oral polio vaccine (Sabin vaccine) |
| 1963 |
First vaccine for measles |
| 1967 |
First vaccine for mumps |
| 1970 |
First vaccine for rubella |
| 1977 |
First vaccine for pneumonia (Streptococcus pneumoniae) |
| 1978 |
First vaccine for meningitis (Neisseria meningitidis) |
| 1980 |
Smallpox declared eradicated worldwide due to vaccination efforts |
| 1981 |
First vaccine for hepatitis B (first vaccine to target a cause of cancer) |
| 1984 |
First vaccine for chicken pox |
| 1985 |
First vaccine for Haemophilus influenzae type b (HiB) |
| 1989 |
First vaccine for Q fever |
| 1990 |
First vaccine for Hantavirus hemorrhagic fever with renal syndrome |
| 1991 |
First vaccine for hepatitis A |
| 1998 |
First vaccine for Lyme disease |
| 1998 |
First vaccine for rotavirus |
| 2003 |
First nasal influenza vaccine approved in U.S. (FluMist) |
| 2003 |
First vaccine for Argentine hemorrhagic fever. |
| 2006 |
First vaccine for human papillomavirus (which is a cause of cervical cancer) |
| 2012 |
First vaccine for hepatitis E |
| 2012 |
First quadrivalent (4-strain) influenza vaccine |
| 2015 |
First vaccine for enterovirus 71, one cause of hand foot mouth disease |
| 2015 |
First vaccine for malaria |
| 2015 |
First vaccine for dengue fever |
| 2019 |
First vaccine for Ebola approved |
| 2020 |
First vaccine for COVID-19. |
