What is POLG disease that was recently mentioned in news?

Question

Prince Frederik of Luxembourg, 22, recently died from a rare genetic disease called POLG. POLG is a mitochondrial disorder that prevents cells from producing enough energy, leading to organ failure. It primarily affects the brain, nerves, muscles, liver, and sometimes vision. Patients often become bedridden and lose the ability to perform daily activities. The disease is caused by mutations in the POLG and POLG2 genes, affecting mitochondrial replication. Symptoms range from muscle weakness and seizures to liver failure and difficulty walking. There is no cure; treatment focuses on symptom management and quality of life improvement.

GKToday Admin · Accepted Answer

A genetic mitochondrial disorder Prince Frederik of Luxembourg, 22, recently died from a rare genetic disease called POLG. POLG is a mitochondrial disorder that prevents cells from producing enough energy, leading to organ failure. It primarily affects the brain, nerves, muscles, liver, and sometimes vision. Patients often become bedridden and lose the ability to perform daily activities. The disease is caused by mutations in the POLG and POLG2 genes, affecting mitochondrial replication. Symptoms range from muscle weakness and seizures to liver failure and difficulty walking. There is no cure; treatment focuses on symptom management and quality of life improvement.

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