Answer: Cadmium
Notes: Itai-itai disease was the documented case of mass cadmium poisoning in Toyama Prefecture, Japan, starting around 1912. The cadmium poisoning caused softening of the bones and kidney failure. This disease is the most severe form of chronic Cd poisoning caused by prolonged oral Cd ingestion. It developed in numerous inhabitants of the Jinzu River basin in Toyama Prefecture, Japan, an area most severely polluted by Cd that originated from a zinc mine located upstream.
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