Tata Institute of Fundamental Research, Bengaluru
Recently, researchers at the National Centre for Biological Sciences (NCBS), Tata Institute of Fundamental Research (TIFR), Bengaluru, developed a deep-learning tool called Disobind. Disobind predicts how intrinsically disordered proteins (IDP) bind to their partner proteins. Intrinsically Disordered Proteins (IDPs) are shapeshifting proteins without fixed structure, crucial for cell signalling, gene regulation, and protein movement. Their flexibility makes them hard to study using traditional structural biology methods. Disobind uses protein language models trained on millions of protein sequences.
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