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Q. With reference to the “Hi-C chromosomal conformation capture” technique, as used in the reconstruction of the woolly mammoth 3D genome, consider the following statements:
  1. It measures metabolic activity of ancient organisms.
  2. It reconstructs preserved chromosome 3D structure from fossils.
  3. It identifies single nucleotide mutations in ancient DNA.
  4. It traces migration patterns via isotopic signatures.
Select the correct answer using the codes below:
Answer: Only 2
Notes: Hi-C is a genomic technique that captures physical proximities between chromosomal regions to map the 3D architecture of chromosomes, especially as applied to reconstructing fossil chromosomes. It does not measure metabolic activity, detect single nucleotide mutations, or analyze isotopic signatures for migration tracing.
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