Consider the following statements:

Genome editing brings desired changes in the genome by using site directed nuclease (SDN).

Clustered regularly interspaced palindromic repeat (CRISPR) system allows for targeted intervention at the genome sequence.

Genome editing involves the introduction of foreign genetic material.

Which of the statements given above are correct?

Question

Genome editing allows to bring about desired changes in the genome by using site directed nuclease (SDN) or sequence specific nuclease (SSN). Nuclease is an enzyme which cleaves through nucleic acid — the building block of genetic material.
Clustered regularly interspaced palindromic repeat (CRISPR) system allows for targeted intervention at the genome sequence. Depending on the nature of the edit that is carried out, the process is divided into three categories — SDN 1, SDN 2 and SDN 3.
Both SDN 1 and SDN 2 do not involve alien genetic material and the end result is indistinguishable from conventionally bred crop varieties. On the other hand, SDN3 process involves larger DNA elements or full-length genes of foreign origin which makes it similar to Genetically modified organisms (GMO) development.
Genetically modified organisms (GMO) involve modification of the genetic material of the host by introduction of a foreign genetic material.
The basic difference between genome editing and genetic engineering is that while the former does not involve the introduction of foreign genetic material, the latter does.

GKToday Admin · Accepted Answer

Only 1 & 2

Genome editing allows to bring about desired changes in the genome by using site directed nuclease (SDN) or sequence specific nuclease (SSN). Nuclease is an enzyme which cleaves through nucleic acid — the building block of genetic material.
Clustered regularly interspaced palindromic repeat (CRISPR) system allows for targeted intervention at the genome sequence. Depending on the nature of the edit that is carried out, the process is divided into three categories — SDN 1, SDN 2 and SDN 3.
Both SDN 1 and SDN 2 do not involve alien genetic material and the end result is indistinguishable from conventionally bred crop varieties. On the other hand, SDN3 process involves larger DNA elements or full-length genes of foreign origin which makes it similar to Genetically modified organisms (GMO) development.
Genetically modified organisms (GMO) involve modification of the genetic material of the host by introduction of a foreign genetic material.
The basic difference between genome editing and genetic engineering is that while the former does not involve the introduction of foreign genetic material, the latter does.

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