New research reveals that genetic mutations in Huntington's Disease (HD) can have delayed effects, impacting disease progression over time. Huntington’s Disease (HD) is a genetic condition causing gradual loss of brain cell function, leading to their death. It affects brain regions regulating voluntary movement, memory, and decision-making, primarily the basal ganglia and brain cortex. HD is caused by a mutation in the HTT gene, which produces huntingtin protein crucial for neuron function. Mutated huntingtin proteins have abnormal shapes, damaging and killing neurons. HD is inherited; each child of an affected parent has a 50% chance of developing the disease. It affects 3 to 7 out of 100,000 people, primarily of European ancestry.
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