Study shows Albumin as better indicator of Diabetes

A study by the scientists from National Chemical Laboratory, Pune indicates levels of free albumin and albumin attached to glucose molecules in the blood can be a better diagnostic test for diabetes.

Present Procedure

Most tests at present, use levels of glycated (or glucose-bound) haemoglobin in blood for diagnosis of diabetes. This is subject to large variations due to factors like stress levels, time of collection, diet and medications taken previous day etc.
Glycation refers to the process of binding of glucose to protein or lipid molecules. The glucose molecules get attached to the Hemoglobin in the blood. The level of glucose bound haemoglobin indicates the diabetic condition of an individual.

Challenges with the current procedure

The average lifespan of the Hemoglobin is four months. Hence the test results predict the diabetic condition of an individual from the previous four months.
The levels of glycated haemoglobin in blood are influenced by many factors like anaemia, iron deficiency, pregnancy. Hence the current results may not necessarily indicate accurate results.

New Study

The new researches have shown that glycation of both albumin and haemoglobin occurs at lower levels of albumin in blood. When the albumin level decreases or gets saturated with bound glucose, other proteins like haemoglobin are exposed to glucose and their glycation increases. Hence it is predicted that levels of albumin and glycated albumin can also help in predicting the onset of diabetes.
The new study proposes albumin and glycated albumin levels quantified in conjunction with glycated haemoglobin can provide for better diagnosis and management of diabetes.

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