National Centre for Cell Science: The Cellular Mechanism of Huntington Disease discovered

On March 20, 2020, the National Centre for Cell Science have found that the pathogenic protein called the Huntingtin Protein causes decrease in overall protein production.

What is Huntington Disease?

The disease is a genetic disorder that declines cognitive abilities, impairs coordination of balance and movement, memory lapses, mood swings and personality changes.

The disease is caused due to the mutation of the gene called HTT. The major function of these genes is to produce protein called Huntingtin. A normal gene gives the right instruction to produce these proteins. A mutated gene gives faulty instructions. This disrupts the normal functioning of the brain and results in Huntington disease.

The Discovery

The Scientists have found that in a diseased person the Huntingtin protein interfered with the protein production of the cells. This is how wrong instructions are sent, mainly due to faulty protein level. They also reduced the level of protein production of a normal cell.




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